Elizabeth A. Proctor, David D. Mowrey, Nikolay V. Dokholyan
Publications
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β-Methylamino-L-alanine substitution of serine in SOD1 suggests a direct role in ALS etiology
Jul 19, 2019
Molecular Basis of Action of a Small-Molecule Positive Allosteric Modulator Agonist at the Type 1 Cholecystokinin Holoreceptor
Dec 19, 2018
Aditya J. Desai, Ingrid Mechin, Karthigeyan Nagarajan, Celine Valant, Denise Wootten, Polo C. H. Lam, Andrew Orry, Ruben Abagyan, Anil Nair, Patrick M. Sexton, Arthur Christopoulos, and Laurence J. Miller
High Throughput Functional Evaluation of KCNQ1 Decrypts Variants of Unknown Significance
Nov 01, 2018
Carlos G. Vanoye, PhD, Reshma R. Desai, MS, Katarina L. Fabre, MS, Shannon L. Gallagher, MS, Franck Potet, PhD, Jean-Marc DeKeyser, MS, Daniela Macaya, PhD, Jens Meiler, PhD, Charles R. Sanders, PhD, and Alfred L. George Jr., MD
TRPA1 ankyrin repeat six interacts with a small molecule inhibitor chemotype
Oct 19, 2018
Wei Chou Tseng, David C. Pryde, Katrina E. Yoger, Karen M. Padilla, Brett M. Antonio, Seungil Han, Veerabahu Shanmugasundaram, and Aaron C. Gerlach
p62-Dependent Phase Separation of Patient-Derived KEAP1 Mutations and NRF2
Aug 20, 2018
E. W. Cloer, P. F. Siesser, E. M. Cousins, D. Goldfarb, D. D. Mowrey, J. S. Harrison, S. J. Weir, N. V. Dokholyan, M. B. Majora
PF-06526290 can both enhance and inhibit conduction through voltage-gated sodium channels
Mar 17, 2018
Lingxin Wang, Shannon G Zellmer, David M Printzenhoff and Neil A Castle
A comprehensive Approach to Identifying Repurposed Drugs to Treat SCN8A Epilepsy
Feb 05, 2018
Talia A. Atkin, Chani M. Maher, Aaron C. Gerlach, Bryant C. Gay, Brett M. Antonio, Sonia C. Santos, Karen M. Padilla, JulieAnn Rader, Douglas S. Krafte, Matthew A. Fox, Gregory R. Stewart, Slavé Petrovski, Orrin Devinsky, Matthew Might, Steven Petrou, David B. Goldstein
Discovery and in Vitro Optimization of 3‐Sulfamoylbenzamides as ROMK Inhibitors
Jan 19, 2018
Matthew F. Sammons, Sujay V. Kharade, Kevin J. Filipski, Markus Boehm, Aaron C. Smith, Andre Shavnya, Dilinie P. Fernando, Matthew S. Dowling, Philip A. Carpino, Neil A. Castle, Shannon G. Zellmer, Brett M. Antonio, James R. Gosset, Anthony Carlo, and Jerod S. Denton
G4941K substitution in the pore-lining S6 helix of the skeletal muscle ryanodine receptor increases RyR1 sensitivity to cytosolic and luminal Ca2+
Dec 18, 2017
Le Xu, David D. Mowrey, Venkat R. Chirasani, Ying Wang, Daniel A. Pasek, Nikolay V. Dokholyan, and Gerhard Meissner
GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K2P) channel opener, reduces rat dorsal root ganglion neuron excitability
Nov 19, 2017
Alexandre J C Loucif, Pierre-Philippe Saintot, Jia Liu, Brett M Antonio, Shannon G Zellmer, Katrina Yoger, Emma L Veale, Anna Wilbrey, Kiyoyuki Omoto, Lishuang Cao, Alex Gutteridge, Neil A Castle, Edward B Stevens, Alistair Matie